Both Diseases On The Prion Spectrum
Neurodegenerative disease is the fastest-growing cause of death in the world. It’s time to expand the conversation immediately.
Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease, also known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.”
President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. Unfortunately, Prusiner’s science is being ignored and we all are facing a public health disaster because of the negligence and reckless disregard for public health.
TSE is a spectrum disease also known as prion disease. The spectrum includes Alzheimer’s disease, Parkinson’s disease and an extremely aggressive version known as Creutzfeldt-Jakob disease. Prusiner claims that all forms of TSE are caused by infectious proteins known as prions (PREE-ons).
The prion spectrum varies in severity. It also varies depending on which region of the brain is impacted first. When the presenting symptom is memory loss, the diagnoses flow along the following chart.
Alzheimer’s disease and Creutzfeldt-Jakob disease (CJD) are essentially the same disease at different points on the same spectrum. Misdiagnosis, suppression of diagnoses, misinformation and mismanagement are contributing to the epidemic.
“Creutzfeldt-Jakob disease behaves like Alzheimer’s disease on steroids,” said Dr. Jennifer Majersik, an associate professor of neurology at the University of Utah.
According to neuroscientists Dr. Laura Manuelidis, at least 25 percent of Alzheimer’s diagnoses are not Alzheimer’s disease. These misdiagnoses are actually CJD, which is further up the prion spectrum. CJD, without dispute, is extremely infectious to caregivers and loved ones. Millions of cases of deadly CJD are being misdiagnosed as Alzheimer’s disease. Millions of patients and caregivers are being misinformed, misguided and exposed to an aggressive disease. Misdiagnosis and misinformation regarding prion disease is a matter of life and death. The mismanagement doesn’t end here.
“There is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine.
Creutzfeldt-Jakob disease often is confused with Alzheimer’s disease because they are very similar and both are fatal. CJD is caused by a more aggressive mutation of the deadly prion than Alzheimer’s disease. The only difference that the medical community discusses is the pace of disease progression. CJD is usually very aggressive and can kill within weeks or months of diagnosis.
Prion disease causes memory loss, impaired coordination, and abnormal movements. It’s not known which patients with brain disease become infectious or when, but both CJD and Alzheimer’s patients are being mismanaged. Informed neurologists won’t touch patients with these symptoms because of the risk of transmission. They are making diagnoses from across the room.
Unfortunately, caregivers and family members are not being warned about the infectivity of CJD and Alzheimer’s disease. The bodily fluids, including blood, saliva, mucus, urine and feces transmit the disease. It’s impossible to sterilize items contaminated with the deadly prions. Millions of patients and caregivers are being misinformed, misguided and exposed to an aggressive disease.
Misdiagnosis and misinformation regarding prion disease is a matter of life and death. The mismanagement doesn’t end here. As such, spouses of those with “Alzheimer’s” disease, for example, are 600 percent more likely to contract the infectious disease.
On a larger level, entire communities and watersheds are at risk of permanent contamination from just a single victim, not to mention thousands of infectious victims. Alzheimer’s disease and CJD are an environmental nightmare–a real-world version of Pandora’s lunchbox.
Infectious waste has become a major part of the equation. These forms of brain disease are now spreading to wildlife, livestock and back to humans because of sewage mismanagement and something the industry calls biosolids, which is another name for highly infectious sewage sludge.
Wastewater treatment plants are collecting points for prions from infected humans. The sewage treatment process can’t stop prions from migrating, mutating and multiplying before being discharged into the environment where they can kill again. Wastewater treatment plants are spreading infectious waste far and wide because they are incapable of stopping prions. As such, all by-products and discharges from wastewater treatment plants are infectious waste, which are contributing to the global epidemic of neurodegenerative disease among humans, wildlife and livestock. Sewage treatment plants can’t detect or stop prions.
The U.S. Environmental Protection Agency (EPA) has confirmed that prions are in sewage and that there has been no way to detect them or stop them. As such, the EPA has never issued guidance on prion management within wastewater treatment plants. Unfortunately, the EPA’s risk assessment on sewage sludge and biosolids were prepared before the world of science knew about prions. The agency continues to cling to it’s antiquated sludge rule crafted back in the dark ages. It does, however, consider prions a “emerging contaminant of concern.” Meanwhile, its outdated risk assessments are promoting a public health disaster.
“Since it’s unlikely that the sewage treatment process can effectively stop prions, adopting measures to prevent the entry of prions into the sewer system is advisable,” said the Toronto Department of Health, November 2004.
We explore that failure in policy and protocol elsewhere on this website. Suffice it to say now that prion disease is being mismanaged on many levels around the world. As such, we have an epidemic of neurological disorders among people and wildlife around the world now. There is no reason to assume that livestock are immune from the same epidemic.
Prions are unstoppable and the pathogen spreads through the bodily fluids of victims. Studies confirm that people and animals dying of prion disease contaminate the environment around them because infectious prions are in the urine, feces, blood, mucus and saliva of each victim. These infectious bodily fluids are contributing to the rapid spread of Alzheimer’s and other mutations of prion disease.
Prions shed from humans are the most deadly mutation. Prions from human victims demand more respect than radiation. Infected surgical instruments, for example, are impossible to sterilize and hospitals throw them away. Many factors are contributing to the prion epidemic.
Prions are now the X factor and the common thread among most forms of neurodegenerative disease. Industry and government are not accounting for prions or regulating them. They are ignoring these deadly proteins completely, which violates the United States’ Bioterrorism Preparedness and Response Act of 2002. Other nations also are ignoring laws developed to protect food, air and water.
The Government’s Perspective On CJD
Sporadic CJD: the disease appears with no known risk factors. It accounts for about 85 percent of all cases. Despite the smokescreen of misinformation, these cases are actually acquired due to exposure to prion contamination, which is widespread and spreading further every day.
Hereditary CJD: person has a family history or tests positive for the gene mutation associated with CJD. Only about 5 percent to 10 percent of CJD cases in the U.S. are hereditary.
Acquired CJD: disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. Food and water contamination are now major pathways.
Initially, individuals with CJD experience problems with muscular coordination, impaired memory and judgment and vision, and personality changes. As the illness progresses, memory impairment becomes severe, and individuals develop involuntary muscle jerks and lose their sight. CJD causes more rapid deterioration of an individual’s abilities than Alzheimer’s disease or most other types of dementia.
Currently, there is no single diagnostic test for CJD. A physician usually rules out treatable forms of dementia, such as encephalitis or chronic meningitis. It’s estimated that at least 25 percent of Alzheimer’s disease diagnoses are wrong. In these cases, the underlying disease is actually CJD, which means that millions of people around the world are walking incubators and prion distributors.
A spinal tap, an electroencephalogram (EEG), computerized tomography (CT) and magnetic resonance imaging (MRI) are all forms of testing and evaluations to make the diagnosis of CJD, but the only way to confirm CJD is by brain biopsy or autopsy.
Like Alzheimer’s disease, there is no effective treatment for CJD. Treatment is aimed at easing symptoms and making the individual as comfortable as possible. Medication can help relieve pain if it occurs.
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Gary Chandler is a prion expert. He is the CEO of Crossbow Communications, author of several books and producer of documentaries about health and environmental issues around the world. Chandler is connecting the dots to the global surge in neurodegenerative disease, including Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and other forms of prion disease. The scientific name for prion disease is transmissible spongiform encephalopathy. The operative word is “transmissible.”