Granalix BioTechnologies has developed a new treatment for those with Alzheimer’s disease. The company introduced GranaGard™ a food supplement based on pomegranate oil that helps prevent neurodegenerative disease.

GranaGard, is a submicron Pomegranate Seed Oil (PSO) emulsion, and is an innovative formulation of one of the strongest natural antioxidants, Punicic acid (an Omega 5 lipid), which constitutes 80 percent of PSO. The novel patented formulation was shown to delay disease onset and prevent neuronal death in a model of genetic prion disease and to reduce disease burden in a mouse model of Multiple Sclerosis, while showing no toxicity after long term administration. In both diseases, GranaGard administration results in reduction of brain lipid oxidation, which is caused by increased levels of reactive oxygen species (ROS).

Ruth Gabizon, Founder and acting CEO of Granalix BioTechnologies, explained,

“Reactive Oxygen species (ROS) are chemically active molecules that can lead to significant damage to cells, and in particular in the central nervous system.

It is therefore widely accepted that this chemical agent contributes to chronic inflammation and neurodegenerative diseases. And while antioxidants that can counteract ROS are ubiquitously present in a healthy human diet, their activity is limited by chemical degradation, poor bioavailability, reduced distribution to the CNS, and sub-pharmacological doses.

To overcome these limitations, we generated GranaGard, a novel neuro-protective formulation with high bioavailability.

In addition to its protective role in subjects at risk of neurodegenerative conditions, GranaGard is expected to be effective for general neurological well-being for the larger public. We are also currently testing GranaGard for its effect in various non-neurological diseases and as a protective agent during intense exercise.”

PSO submicron droplets have several advantages. First, the nano formulation may avoid the first passage of the oil through the liver, thereby enhancing the availability of the droplets to other organs such as the CNS. GranaGard is then able to enter the brain and protect membrane lipids from ROS attacks that occur as a result of both every-day efforts and pathological events. In vivo, Punicic Acid is metabolized into Conjugated Linoleic Acid (CLA), a compound known for its neuroprotective and other beneficial effects. When mice are given the GranaGard formulation, CLA was found to accumulate in the brain and can directly exert its neuroprotective effect.

Neurodegenerative diseases, such as Alzheimer’s disease, Creutzfeldt-Jakob disease, Parkinson’s or Amyotrophic Lateral Sclerosis (ALS) are late onset brain disorders that together affect millions of people around the globe.

Alzheimer’s disease is already the 5th-leading cause of death for people 65 or older in the US. It’s also the fastest-growing cause of death globally.

“GranaGard can currently be purchased at the Company’s website. We are seeking additional partners for worldwide distribution,” added Prof. Gabizon. GranaGard™ is produced by Supherb and can be purchased at the Company’s website at https://granalix.com/

Granalix BioTechnologies focuses on developing science-based novel formulations of natural antioxidants that can be used for the prevention and treatment of neurodegenerative conditions. The Company was established in 2014 by Prof. Ruth Gabizon from the Department of Neurology at Hadassah Medical Center, Jerusalem, Israel and Prof. Shlomo Magdassi at the Casali Center for Applied Chemistry, the Institute of Chemistry and the Center for Nanoscience and Nanotechnology at the Hebrew University of Jerusalem.

Prion disease is now the fastest-growing cause of death in the world. The medical term for prion disease is transmissible spongiform encephalopathy, which includes ALS, Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease, mad cow disease, chronic wasting disease.

There are proven strategies to help avert neurodegenerative disease, including nutrition, exercise and prion aversion. There is not a cure for prion disease. Preview and order the eBook now to defend yourself and your family.

The post Pomegranate Seeds Treat Neurodegenerative Disease appeared first on Neuroscience News.