Pomegranate Seeds Treat Neurodegenerative Disease

Alzheimer’s Disease Treatment Delivers Powerful Antioxidant

Granalix BioTechnologies has developed a new treatment for those with Alzheimer’s disease. The company announced the availability of GranaGard™ a food supplement based on pomegranate oil that helps prevent neurodegeneration.

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GranaGard, is a submicron Pomegranate Seed Oil (PSO) emulsion, and is an innovative formulation of one of the strongest natural antioxidants, Punicic acid (an Omega 5 lipid), which constitutes 80 percent of PSO. The novel patented formulation was shown to delay disease onset and prevent neuronal death in a model of genetic prion disease (a form of Mad Cow Disease)[i] and to reduce disease burden in a mouse model of Multiple Sclerosis[ii], while showing no toxicity after long term administration. In both diseases, GranaGard administration results in reduction of brain lipid oxidation, which is caused by increased levels of reactive oxygen species (ROS).

Prof. Ruth Gabizon, Founder and acting CEO of Granalix BioTechnologies, explained, “Reactive Oxygen species (ROS) are chemically active molecules that can lead to significant damage to cells, and in particular in the central nervous system. It is therefore widely accepted that this chemical agent contributes to chronic inflammation and neurodegenerative diseases. And while anti-oxidants that can counteract ROS are ubiquitously present in a healthy human diet, their activity is limited by chemical degradation, poor bioavailability, reduced distribution to the CNS, and sub-pharmacological doses.

Alzheimer's disease treatment

To overcome these limitations, we generated GranaGard, a novel neuroprotective formulation with high bioavailability. In addition to its protective role in subjects at risk of neurodegenerative conditions, GranaGard is expected to be effective for general neurological wellbeing for the larger public. We are also currently testing GranaGard for its effect in various non-neurological diseases and as a protective agent during intense exercise.”

PSO submicron droplets have several advantages. First, the nano formulation may avoid the first passage of the oil through the liver, thereby enhancing the availability of the droplets to other organs such as the CNS. GranaGard is then able to enter the brain and protect membrane lipids from ROS attacks that occur as a result of both every-day efforts and pathological events. In vivo, Punicic Acid is metabolized into Conjugated Linoleic Acid (CLA), a compound known for its neuroprotective and other beneficial effects. When mice are given the GranaGard formulation, CLA was found to accumulate in the brain and can directly exert its neuroprotective effect.

Neurodegenerative diseases, such as Alzheimer’s disease, Creutzfeldt-Jacob disease, Parkinson’s or Amyotrophic Lateral Sclerosis (ALS) are late onset brain disorders that together affect millions of people around the globe. Alzheimer’s disease is already the 5th leading cause of death for people aged 65 or older in the US. It’s also the fastest-growing cause of death globally. Currently, there are no preventive or curative treatments for these conditions.

“GranaGard can currently be purchased at the Company’s website. We are seeking additional partners for worldwide distribution,” added Prof. Gabizon. GranaGard™ is produced by Supherb and can be purchased at the Company’s website at http://www.granalix.com.

Granalix BioTechnologies focuses on developing science-based novel formulations of natural antioxidants that can be used for the prevention and treatment of neurodegenerative conditions. The Company was established in 2014 by Prof. Ruth Gabizon from the Department of Neurology at Hadassah Medical Center, Jerusalem, Israel and Prof. Shlomo Magdassi at the Casali Center for Applied Chemistry, the Institute of Chemistry and the Center for Nanoscience and Nanotechnology at the Hebrew University of Jerusalem.

About Gary Chandler

Gary Chandler is an author, advocate and strategist on health and environmental issues.
This entry was posted in Alzheimer's Disease, Alzheimer's Disease Prevention, Alzheimer's Disease Treatment, Nutrition and tagged , , , . Bookmark the permalink.

One Response to Pomegranate Seeds Treat Neurodegenerative Disease

  1. Juriciah says:

    I have been suffering from amyotrophic laterals sclerosis (ALS) disease for the last three years and had constant pain, especially in my knees. my first sign that something was wrong, was my slurred speech. And then the inability to eat without getting choked, strangled, and coughing.Throughout my three years ordeal, i was able to walk with assistance nothing was really working to help my condition.I went off the riluzole (with the doctor’s knowledge) and started on amyotrophic lateral sclerosis herbal formula i ordered from Health Herbal Clinic, Just 7 weeks into the Herbal formula treatment I had great improvements with my slurred speech, there is no case of constant pain and chest tightness since treatment, visit Health Herbal Clinic official website www. healthherbalclinic. net or email info@ healthherbalclinic. net. This treatment is incredible!

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