Food, Water, Air Contamination Fueling Brain Disease

Alzheimer’s Disease, Autism Now Industrial Diseases

The EPA is drawing more attention and criticism than usual lately, but its history of mismanagement is nothing new.

EPA failures regarding wastewater treatment, reuse and the land application of sewage sludge go back decades. For example, sewage sludge was deemed too toxic to dump in the ocean in 1972, so the EPA started pimping it as fertilizer for our food supply, gardens, parks and school grounds.

Sewage sludge certainly has some beneficial nutrients for plants, including phosphorous and nitrogen. Unfortunately, the so-called biosolids also include pathogens, prions, heavy metals, pharmaceutical residues, carcinogens and other harmful ingredients. After all, sewage comes from slaughter houses, nursing homes, hospitals, dental offices, veterinarians, street runoff, factories, and beyond. It also includes all of the things that millions of homes choose to dump.

land application sewage sludge

The EPA never conducted a legitimate risk assessment regarding the land application of sewage sludge. It never issued official policy. It issued something known to industry insiders as the sludge rule back in the 1990s. It’s the government equivalent of a wink-wink.

The EPA stood behind the sludge rule and allowed each state to develop random regulations and practices on sewage discharges. Places such as Milwaukee, Wisconsin started pimping its sewage sludge as fertilizer long ago. In Milwaukee, they branded the toxins Milorganite, which is registered for sale in all 50 states. Farmers are eating the stuff up. So do livestock, crops, gardeners and our wildlife. It’s running off into streams, rivers, lakes and oceans. Tornadoes carry it into the sky and into homes, offices and schools. The treated wastewater is discharged to Lake Michigan, where Chicago and other municipalities tap drinking water.

Since the EPA’s infamous sludge rule darkened our world, we now know about a deadly form of protein known as a prion. Prions are in the bodily fluids of victims, including blood, saliva, mucus, urine, feces, etc.—everything that’s destined for a wastewater treatment plant and a farmer’s field (or a soccer field).

Prions aren’t alive, so they can’t be killed. Wastewater treatment does little more than separate the stuff that floats from the stuff that doesn’t float. What’s left is pumped right back into your world. Including wastewater that’s being touted as drinking water (per the next section, look for the word “prion” in the risk assessments).

Prion disease and Alzheimer's disease

Dr. Stanley Prusiner earned the Nobel Prize in physiology in 1998 for his study of prions and prion disease. Unfortunately, government and industry are ignoring the ramifications of his science. As such, neurodegenerative disease is now the fastest-growing cause of death in the world. The autism epidemic is likely related to the same mismanagement of neurotoxins. Meanwhile, valley fever has evolved into an umbrella term for a variety of ailments spread through infectious waste in soil and air.

Prion disease is prion disease, but misguided public servants are blinding us with pseudo science. We know that prions migrate, mutate, multiply and kill with unparalleled efficiency. Yet, we are being told that various threats are unproven. We are being told that prions deplete themselves.

We are being told that there is no connection between the various forms of prion diseases among humans and other mammals, including Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease, chronic wasting disease, and mad cow disease.

We are told that autism is caused by vaccines, not food and water contamination. We are being told that infectious waste is fertilizer. It’s time to read between the lines and think for ourselves, while we can still think at all.

The wastewater treatment plant in Milwaukee, for example, has been serving people with prion disease for decades. Wastewater treatment plants around the world are prion collectors, incubators and distributors. As more and more people get neurodegenerative disease, the deadlier the waste stream becomes. They have become weapons of mass destruction, yet no regulation exists. Highly toxic garbage in—fertilizer out.

land application sewage sludge and disease

Prions + Pathways = Victims

Humans Transmitting Prion Disease To Wildlife

Thanks to the indiscriminate dumping of sewage sludge laden with prions from sick people, the dairy state is a now a leader in chronic wasting disease among its wildlife. Since wildlife are serving as the proverbial bird in a coal mine, we know that livestock and humans also are being poisoned. The prion pathway goes both directions–people can contract it from infected animals and animals can contract it from human infectious waste (sewage). Few, if any mammals are immune. Few corners of the earth are safe.

The risk assessments for biosolids and wastewater reclamation were prepared before the world of science knew about deadly, unstoppable prions. Prions don’t deplete themselves over time. They don’t have a half-life. They migrate, mutate and multiply. Prions are being mismanaged in a criminal way on an industrial scale.

Although there are several pathways for deadly prion disease to infect a herd, the greatest prion pathway is being ignored. Sick deer, elk, moose and reindeer are just canaries in a proverbial coal mine. You and your family are caught in the crossfire of misinformation and mismanagement. Neurodegenerative disease is now the fastest-growing cause of death in the world.

Municipalities around the world were asked to stop dumping their sewage sludge in rivers and oceans and start dumping the toxic soup onto farms, forests, parks, school grounds, gardens and golf courses. Cities also are dumping the toxins in the deserts around the world, where it bakes and blows back in the faces of the cities that are trying to get rid of the sewage. The death dust from sewage sludge alone includes infectious waste, radioactive waste, heavy metals, carcinogens, pharmaceutical residues and other threats.

Alzheimers disease treatment

Humans Transmitting Brain Disease To Humans

Most forms of neurodegenerative disease are prion disease. The clinical term is transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” Victims are producing and discharging infectious waste. Prions from people are the most deadly and aggressive because people are at the top of the food chain. It’s a vicious cycle. People are giving it back and forth to each other, but in different mutations. People are transmitting prion disease to animals through sewage. Animals are transmitting it to people through milk and meat. Government and industry are fanning the flames.

Thanks to modern sewage disposal (biosolids) and antiquated (if not fraudulent) risk assessments, we’re witnessing a public health disaster that’s still unfolding in the form of autism, Alzheimer’s disease, west Nile virus, Zika virus, chronic wasting disease, mad cow disease, valley fever, meningitis, hepatitis, and other threats to public health.

The spike in autism and Alzheimer’s disease began shortly after we started dumping toxic sewage on open lands in urban and rural areas. The spike in chronic wasting disease and mad cow disease began about the same time. It’s time to divert all sewage sludge to lined landfills to protect human health, animal health and entire watersheds. Infectious waste isn’t fertilizer.

Alzheimer's disease prevention

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Caregivers At Risk In Battle Against Brain Disease

Spouses Of Those With Brain Disease More Likely To Contract Brain Disease

Millions of people are becoming caregivers for friends and family members with Alzheimer’s disease. It’s a silent epidemic that’s creating family crises around the world. In addition to the shock of the sudden dependency, at least some caregivers (family members and professionals) are being misinformed and exposed to deadly pathogens that can spread the disease.

“A good caregiver who understands the disease, its symptoms and progression is crucial to the overall well-being of people with Alzheimer’s disease,” said Dr. Fred Kobylarz, a dementia expert at the Robert Wood Johnson Medical School at Rutgers University. “Alzheimer’s has become pervasive in the United States and around the world. It affects people in all walks of life,” Kobylarz said. “It is a problem that needs action and attention.”

Memory problems are typically one of the first signs of cognitive impairment related to Alzheimer’s disease. Some people with memory problems have a condition called mild cognitive impairment (MCI). In MCI, people have more memory problems than normal for their age, but their symptoms do not interfere with their everyday lives. Movement difficulties and problems with the sense of smell have also been linked to MCI. Older people with MCI are at greater risk for developing Alzheimer’s disease, but not all do. Some may even go back to normal cognition.

The first symptoms of Alzheimer’s disease vary from person to person. For many, decline in non-memory aspects of cognition, such as speech, vision, and impaired reasoning or judgment, may signal the very early stages of Alzheimer’s disease.

Alzheimer's disease treatment

Researchers are studying biomarkers (brain images, cerebrospinal fluid, and blood) to see if they can detect early changes in the brains of people with MCI and in cognitively normal people who may be at greater risk for Alzheimer’s. Studies indicate that such early detection may be possible, but more research is needed before these techniques can be relied upon to diagnose Alzheimer’s disease in everyday medical practice.

For instance, people early on might show signs of memory loss that don’t affect their ability to function day to day. “Some memory loss can also be a sign of the normal aging process,” Kobylarz explained.

“Families should look for memory impairment and trouble managing aspects of their daily lives — like paying bills or taking their medication,” he said.

It’s also important to know your family history and share that with your doctors, Kobylarz said. Though older age is the biggest risk factor for Alzheimer’s, he explained, genetics and family history also play a role.

If you notice worrisome changes in an older family member, talk with a doctor, he said.

Scientists don’t yet fully understand what causes Alzheimer’s disease in most people. There is a genetic component to some cases of early-onset Alzheimer’s disease. Late-onset Alzheimer’s arises from a complex series of brain changes that occur over decades. The causes probably include a combination of genetic, environmental, and lifestyle factors. The importance of any one of these factors in increasing or decreasing the risk of developing Alzheimer’s may differ from person to person.

Alzheimers disease epidemic

To diagnose Alzheimer’s, doctors often:

  • Ask the person and a family member or friend questions about overall health, past medical problems, ability to carry out daily activities, and changes in behavior and personality;
  • Conduct tests of memory, problem solving, attention, counting, and language;
  • Carry out standard medical tests, such as blood and urine tests, to identify other possible causes of the problem; and
  • Perform brain scans, such as computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET), to rule out other possible causes for symptoms.

These tests may be repeated to give doctors information about how the person’s memory and other cognitive functions are changing over time. If the diagnosis is Alzheimer’s, beginning treatment early in the disease process may help preserve daily functioning for some time, even though the underlying disease process cannot be stopped or reversed. An early diagnosis also helps families plan for the future. They can take care of financial and legal matters, address potential safety issues, learn about living arrangements, and develop support networks.

In addition, an early diagnosis gives people greater opportunities to participate in clinical trials that are testing possible new treatments for Alzheimer’s disease or other research studies.

Alzheimer’s disease can be definitely diagnosed only after death, by linking clinical measures with an examination of brain tissue in an autopsy.

People with memory and thinking concerns should talk to their doctor to find out whether their symptoms are due to Alzheimer’s or another cause, such as stroke, tumor, Parkinson’s disease, sleep disturbances,side effects of medication, an infection, or a non-Alzheimer’s dementia. Some of these conditions may be treatable and possibly reversible.

Alzheimer’s cannot yet be cured, but medications and lifestyle changes can often help slow the progression of the disease, Kobylarz said. This requires the doctor, patient and family to work together to develop a plan to maintain cognitive function, he added.

Caring for a person with Alzheimer’s disease can have high physical, emotional, and financial costs. The demands of day-to-day care, changes in family roles, and decisions about placement in a care facility can be difficult. There are several evidence-based approaches and programs that can help, and researchers are continuing to look for new and better ways to support caregivers.

Becoming well-informed about the disease is one important long-term strategy. Programs that teach families about the various stages of Alzheimer’s and about ways to deal with difficult behaviors and other caregiving challenges can help.

Prion disease and Alzheimer's disease

Which Forms Of Neurodegenerative Diseaese Are Contagious

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing prions (PREE-ons) and prion disease, also known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” Prions are a deadly and unstoppable form of protein that migrates, mutates, multiplies and kills with unparalleled efficiency. Prions cause fatal neurodegenerative diseases in humans and animals by converting the cellular prion protein PrPC into aggregation-prone PrPSc.

President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. Unfortunately, Prusiner’s science is being ignored and we all are facing a public health disaster because of the negligence and reckless disregard for public health. Misinformed caregivers, family members, healthcare workers and others are caught in the crossfire of a deadly contagion known as a prion.

TSE is a spectrum disease also known as prion disease. The spectrum includes Alzheimer’s disease, Parkinson’s disease and an extremely aggressive version known as Creutzfeldt-Jakob disease. Prusiner claims that all forms of TSE are caused by infectious prions. The prion spectrum varies in severity. It also varies depending on which region of the brain is impacted first. When the presenting symptom is memory loss, the diagnoses flow along the following chart.

prion disease spectrum

Prion disease causes memory loss, impaired coordination, and abnormal movements. Abnormal proteins are now associated with autism. In fact, it appears that the biggest difference between the neurodegenerative disease spectrum and autism spectrum disorders is age. Both spectrums share common environmental causes and pathologies.

Caregivers Misinformed

It’s not known which patients with brain disease become infectious or when, but both CJD and Alzheimer’s patients are being mismanaged. Informed neurologists won’t touch patients with these symptoms because of the risk of transmission. They are making diagnoses from across the room.

“Creutzfeldt-Jakob disease behaves like Alzheimer’s disease on steroids,” said Dr. Jennifer Majersik, an associate professor of neurology at the University of Utah.

According to neuroscientists Dr. Laura Manuelidis, at least 25 percent of Alzheimer’s diagnoses are not Alzheimer’s disease. These misdiagnoses are actually CJD, which is further up the prion spectrum. CJD, without dispute, is extremely infectious to caregivers and loved ones but it has not been declared a reportable disease in the U.S. and many other nations. Millions of cases of deadly CJD are being misdiagnosed as Alzheimer’s disease. Millions of patients and caregivers are being misinformed, misguided and exposed to an aggressive disease. Misdiagnosis and misinformation regarding prion disease is a matter of life and death. The disease is now striking young people, including teenagers, with much greater frequency. It’s also killing clusters of people in the same communities with greater frequency. The mismanagement doesn’t end here.

Studies confirm that people and animals dying of prion disease contaminate the environment around them because infectious prions are in the urine, feces, blood, mucus and saliva of each victim. These infectious bodily fluids are contributing to the rapid spread of Alzheimer’s and other mutations of prion disease.

“There has been a resurgence of this sort of thinking, because there is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

Alzheimer's disease research

Caregivers and other stakeholders are caught in the crossfire of misinformation and mismanagement. At the most basic level, this means that a sneeze, a drinking glass and eating utensils are permanent pathways of disease transmission. Anything that ever comes into contact with the bodily fluids of a victim is impossible to sterilize.

On a larger level, it means that entire communities and watersheds are at risk of permanent contamination from just a single victim, not to mention thousands of infectious victims. Alzheimer’s disease is an environmental nightmare–it’s a real-world version of Pandora’s box.

A study published in the journal Nature adds to the evidence about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the claim. Meanwhile, there is absolutely no evidence to the contrary. Even wildlife are contracting brain disease from people because of the dumping of infectious waste on farms, ranches and forests.

Surgical instruments infected with prions, for example, are impossible to sterilize and hospitals throw them away. Prions are in the blood, saliva, urine, feces, mucus, and bodily tissue of its victims. Many factors are contributing to the epidemic. Prions are now the X factor. Industry and government are not accounting for prions or regulating them. They are ignoring the threat completely, which violates the Bioterrorism Preparedness and Response Act of 2002 in the United States. Other nations also are ignoring laws developed to protect food, air and water.

More Mismanagement Of Prion Disease

When the U.S. government enacted the Bioterrorism Preparedness and Response Act of 2002, it classified prions as select agents that pose an extreme risk to food, water and much more. Only two labs in the U.S. were allowed to handle them for research purposes. Unfortunately, the CDC quietly took prions off the list because the regulation criminalized entire industries and several reckless practices.

The U.S. Environmental Protection Agency (EPA) has confirmed that prions are in sewage and that there has been no way to detect them or stop them. As such, the EPA has never issued guidance on prion management within wastewater treatment plants.

land application sewage sludge

Unfortunately, the EPA’s risk assessment on sewage sludge and biosolids were prepared before the world of science knew about prions. The agency continues to cling to it’s antiquated sludge rule crafted back in the dark ages. It does, however, consider prions a “emerging contaminant of concern.” Meanwhile, its outdated risk assessments are promoting a public health disaster. The neurotoxins found in sewage, including heavy metals, also are contributing to the global spike in autism, which follows the same timing and trajectory as the spike in neurodegenerative diseases.

“Since it’s unlikely that the sewage treatment process can effectively deactivate prions, adopting measures to prevent the entry of prions into the sewer system is advisable,” said the Toronto Department of Health, November 2004.

Once unleashed on the environment, prions remain infectious. They migrate, mutate and multiply as they infect crops, water supplies, wildlife, livestock, sea mammals and humans. According to prion researcher Joel Pedersen at the University of Wisconsin, prions in soil become up to 680 times more infectious. From there, they migrate, mutate and multiply. It’s a real world version of Pandora’s Lunchbox.

“Our results suggest that if prions enter municipal wastewater treatment systems, most of the agent would bond to sewage sludge, survive anaerobic digestion, and be present in treated biosolids,” Pedersen said. “Land application of biosolids containing prions represents a route for their unintentional introduction into the environment. Our results emphasize the importance of keeping prions out of municipal wastewater treatment systems.

Pedersen also found that sewage treatment does not inactivate prions. Therefore, prions are lethal, mutating, migrating and multiplying everywhere sewage is dumped.

Prions could end up in sewage treatment plants via slaughterhouses, hospitals, dental offices and mortuaries just to name a few of the pathways. The disposal of sludge represents the greatest risk of spreading prion contamination in the environment. Plus, we know that pathogens, pharmaceutical residue and chemical pollutants found in sewage sludge are taken up by plants and vegetables.”

TSEs also include mad cow disease and chronic wasting disease in the deer family. Few, if any, mammals are immune. Thanks to the mismanagement of infectious waste, including sewage, the animal world is contracting prion disease from humans. They also are passing it among themselves via their own bodily fluids. Species barriers are a myth.

Unfortunately, prions linger in the environment, homes, hospitals, nursing homes, dental offices and beyond infinitely. Prions defy all attempts at sterilization and inactivation. If they can’t stop prions in the friendly and sterile confines of an operating room, they can’t stop them in the wastewater treatment plant.

biosolids land application

The risk assessments prepared by the U.S. EPA for wastewater treatment and sewage sludge are flawed and current practices of recycling this infectious waste is fueling a public health disaster. Many risks are not addressed, including prions and radioactive waste. They don’t mention prions or radiation because there is no answer. Most nations are making the same mistake. We’re dumping killer proteins on crops, parks, golf courses, gardens, ski areas, school grounds and beyond. Wind, rain and irrigation spread these contaminants and many more throughout our communities and watersheds.

Failure to account for known risks is negligent. Crops for humans and livestock grown in sewage sludge absorb prions and become infectious. We’re all vulnerable to neurotoxins and right now due to widespread denial and mismanagement. It’s time to stop the land application of sewage sludge (LASS) in all nations. Safer alternatives exist.

Alzheimer's disease public relations firm

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Tau Proteins Very Similar To Prions

Prion Science Still Unfolding

Neurodegenerative disease is the fastest-growing cause of death in the world. Prion disease is responsible for the vast majority of the surge in humans and other mammals.

Professor Goedert, a program leader at the MRC Laboratory of Molecular Biology in Cambridge, believes our best hope of fighting dementia requires predicting who will get neurodegenerative disease and preventing its onset.

His work has just earned him – along with three other neuroscientists – the Brain Prize for 2018 from the Lundbeck Foundation in Denmark. Worth one million euros, it is the most valuable award there is for brain research.

Goedert won the prize for groundbreaking work dating back to the 1980s that was initiated at the LMB by Aaron Klug and Martin Roth and initially involved Claude Wischik, Tony Crowther, Michal Novak, John Walker, Cesar Milstein, Ross Jakes and Maria Grazia Spillantini.

neuroscience and prions

Using human brain tissues, transgenic mice, cultured cells and purified proteins, Professor Goedert demonstrated – despite considerable initial skepticism – the importance of tau protein in Alzheimer’s disease.

“The brains of people who have died of Alzheimer’s disease have two abnormalities – so-called plaques and tangles. These are protein aggregates,” he explains.

Ultimately, these abnormalities kill nerve cells and brain tissue. Plaques are caused by the clumping together of beta-amyloid protein pieces outside nerve cells, which block cell-to-cell signalling. Tangles, meanwhile, are inside the nerve cells and occur when tau protein assembles into clusters of filaments and becomes insoluble. These are the focus of Goedert’s work.

“We all have tau proteins in the brain. Its function is probably to stabilise microtubules inside cells,” he says.

Microtubules are a cellular transport system, like rails, that help material to move in our bodies.

“But it is not a loss of function disease,” Goedert stressed. “It’s a gain of toxic function. The tau protein is one of many proteins that can stabilise these microtubules.

“It looks like if a portion of it turns into these abnormal structures, it’s not sufficient to disrupt this process. The formation of these inclusions is what causes the disease of the cell.”

A pathological pathway leads from the soluble to insoluble filamentous tau.

“Somewhere along it lies the cause of the disease, in the sense of why the nerve cells degenerate and die, which leads to the symptoms of the disease,” explains Goedert.

“Everybody would agree that something on this pathway causes neurodegeneration. Some would argue that there are aggregate species – not the final filaments, but smaller – that have a very active toxic effect.

“I would think it’s equally likely that if you have loads of these filaments inside cells, over a long period of time they are like space-occupying lesions inside a cell body and particularly inside very fine processes.

“They would disrupt all sorts of things inside the cells, including the transport of materials to the periphery, and then at the end the cell dies.

“In the past 10 years, we’ve also found tau proteins exhibit prion-like properties – they can fold in ways that can be transmitted to soluble tau molecules.”

Prions are the misfolded protein equivalent of viral infections and enable a neurodegenerative disease to spread. In the case of Alzheimer’s disease, it means the tau protein aggregates gradually take over.

Prion disease and Alzheimer's disease

“These aggregates form in a small region of the brain and over a long period of time spread to the brain as a whole, and then symptoms appear. Initially, when you have small numbers of these aggregates, there are no symptoms,” adds Goedert.

Much of the group’s work now is focused on the mechanisms behind the spread. Prions migrate, mutate and multiply. There is no species barrier. As such, other mammals are now contracting brain disease from human sewage.

“If we understand more, we might be in a position to prevent the spread from happening and develop compounds that can prevent the symptoms. In addition, you need to be able to predict who is going to get the disease.

“These very early aggregates that form, before the spread occurs, are probably present in people’s brains for decades before the symptoms appear. If you could detect those and predict at an individual level for example that if a person lives another 20 years they are going to get the disease, then you would be in a position to treat that person and prevent the symptoms,” says Professor Goedert, who is an honorary professor of experimental molecular neurology at the University of Cambridge.

“You could give the compounds to everyone over the age of 50. But every treatment has some sort of side effect. Then you would have to treat people who are perfectly healthy.”

No compounds yet exist to deal with the aggregation of tau proteins. And those that have been trialled to tackle amyloid plaques have so far failed.

“One possibility is that the compounds were perfectly good but were given too late,” suggests Prof Goedert. “I think identifying people at risk of developing the disease at a point when they have no symptoms but have some of these pathologies in the brain is really crucial. These are the biomarkers. But until recently it was not possible to detect these things inside living people.”

Studies of the brains of thousands of people have shown that the vast majority have small numbers of these aggregates. Those who had Alzheimer’s disease had many more of them.

“When you see small numbers of aggregates in the brain, you extrapolate that had the person lived for another 20-30 years, they would have got the disease,” says Goedert.

“More recently, it’s become possible to identify aggregates in the brains of living people using PET (positron emission tomography) scanning. You inject mildly radioactive compounds that bind specifically to the aggregates – they don’t see the protein where it’s not aggregated. Then using imaging techniques, you can detect the aggregates.”

PET scans can now be used to detect both beta-amyloid plaques and aggregated tau protein, although the test is not yet sophisticated enough.

“It’s still very early but I think this is going to revolutionise everything,” says Prof Goedert. “In principle you could take a person and image them every year and see whether the pathology progresses. The problem is resolution. Are you going to detect very small numbers of these things? Over time that will improve – but at the moment it’s not there.

“In the long run, it could be like breast cancer screening for women or colonoscopies for men and women. You would take people at the age of 50 and have a PET scan every five or 10 years.”

Current therapies – cholinesterase inhibitors and glutamate receptor antagonists – treat some of the symptoms of Alzheimer’s disease, but do not tackle the underlying biological causes.

These symptoms often begin with memory lapses and gradually progress through to problems with communication, reasoning and orientation. In the latter stages, patients may have difficulties eating or walking, and become increasingly frail and needing help with all aspects of daily life.

prion disease spectrum

“There are so many people working on it now, one can be reasonably optimistic in terms of the timeframe. It’s reasonably clear now what one has to do,” says Prof Goedert.

Understanding the mechanisms of the disease is key – and the work of Professor Goedert and those he shared the prize with is likely to play a critical role in future treatments. Most recently, he has been examining the structure of the tau filaments.

“This lab is very famous for its cryo-electron microscopy technique, which Richard Henderson got a Nobel Prize for last year, and we are collaborating with the group of Sjors Scheres to look at high resolution structures of these tau filaments for Alzheimer’s disease. It tells you how similar or different they are, which I think has a bearing on the prion-like properties of these aggregates,” he said.

Different tau filaments feature in the distinct neurodegenerative diseases such as Pick’s disease and progressive supranuclear palsy, where they form in the absence of beta-amyloid deposits outside brain cells.

Goedert’s recent work in mouse models and in cell cultures suggests filamentous tau clusters propagate through self-seeding (replication, infection and mutation).

“Experimentally, they do. But proving the mechanism takes place in the human brain is difficult. We must interfere with the process and block to prove the theory,” he said. “In the long run, prevention is the thing to do.”

Goedert shares the 2018 Brain Prize with Bart De Strooper (London and Leuven), Christian Haass (Munich) and John Hardy (London) for their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease.

Although he knows them all, Professor Goedert has not collaborated with the others because they all work primarily on beta amyloid plaques.

Unfortunately, prions migrate, mutate and multiply. There is no species barrier. As such, other mammals are now contracting brain disease from human sewage that’s being dumped into our food and water supplies. Sick wildlife and sick livestock are just the tip of the iceberg. Infectious waste isn’t fertilizer for farms, ranches, golf courses, school grounds, parks, gardens or elsewhere. Spreading infectious waste is now spreading brain disease at the speed of light. Preventing brain disease begins with the truth. http://crossbowcommunications.com/wildlife-contracting-brain-disease-from-biosolids/

Alzheimer's disease prevention

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com

Neil Diamond Retires Due To Parkinson’s Disease

Neurodegenerative Disease Gaining Momentum

After nearly 50 years on the pop charts, Neil Diamond announced his retirement to tackle Parkinson’s disease.

Concert dates in Australia and New Zealand that were set for March and April as part of Mr. Diamond’s 50th anniversary tour have been canceled. With 38 songs in the Top 10 on the Billboard Adult Contemporary charts, he is one of the world’s best-selling artists of all time.

“It is with great reluctance and disappointment that I announce my retirement from concert touring,” Mr. Diamond said in a statement on his website. “I have been so honored to bring my shows to the public for the past 50 years.”

Parkinson's disease Neil Diamond

Mr. Diamond, who turns 77 this week, will continue writing and recording music, but would no longer play to live audiences. As part of the anniversary tour, he had already performed concerts across the United States and Europe, including dates in New York; Nashville; London; and Hamburg, Germany, when he made the announcement.

Mr. Diamond was inducted into the Rock and Roll Hall of Fame in 2011. He will receive a Lifetime Achievement Award at this year’s Grammys.

Mr. Diamond was on his 50th anniversary tour when he announced his retirement from live performances. As part of that tour, he performed at the Royal Farms Arena in Baltimore in June 2017, where he sang probably his best-known and most-beloved hit, “Sweet Caroline.” In the statement announcing his retirement, he cited a line from the song: “This ride has been ‘so good, so good, so good’ thanks to you.”

Neurodegenerative disease is now the fastest-growing cause of the death in the world. It’s vastly undiagnosed and misdiagnosed.

Alzheimer’s disease alone is taking the lives of 50-100 million people now. Despite millions of deaths, experts suggest that the prevalence of the disease will quadruple by 2050, if not sooner. Unfortunately, there is a growing stack of evidence that Alzheimer’s disease and Parkinson’s disease are forms of prion disease–a transmissible disease–which means that millions of caregivers, friends and family members are at risk.

Prion disease and Alzheimer's disease

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing prions (PREE-ons) and prion disease, also known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” Prions are a deadly and unstoppable form of protein that migrates, mutates, multiplies and kills with unparalleled efficiency. Prions cause fatal neurodegenerative diseases in humans and animals by converting the cellular prion protein PrPC into aggregation-prone PrPSc.

President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. Unfortunately, Prusiner’s science is being ignored and we all are facing a public health disaster because of the negligence and reckless disregard for public health. Misinformed caregivers, family members, healthcare workers and others are caught in the crossfire of a deadly contagion known as a prion.

TSE is a spectrum disease also known as prion disease. The spectrum includes Alzheimer’s disease, Parkinson’s disease and an extremely aggressive version known as Creutzfeldt-Jakob disease. Prusiner claims that all forms of TSE are caused by infectious prions. The prion spectrum varies in severity. It also varies depending on which region of the brain is impacted first.

Parkinson’s disease is the second most common diagnosis in the prion spectrum. It’s estimated that between 7-10 million people around the world have Parkinson’s disease today.

The US National Institute for Neurological Disorders and Stroke (NINDS) estimated in a 2006 report that about 50,000 new cases of Parkinson’s disease are diagnosed in the US each year, and the total number of cases in the US is at least 500,000. The true prevalence (total number of cases) of Parkinson’s disease is difficult to assess, because the disease is typically not diagnosed until the disease process is already far advanced. Therefore the actual number of Americans with the disease is almost certainly higher than the diagnostic numbers would suggest.

The prion epidemic is worse in some regions of the world than others. Finland and Iceland are at the top of the list. The United States is third, where deaths from Alzheimer’s disease increased 71 percent from 2000 to 2013. Over the same time, deaths from heart disease decreased 14 percent.

Researchers have more questions than answers, but we know that neurotoxins, head trauma and genetics can all trigger neurodegenerative disease. Unfortunately, that’s where our knowledge gets fuzzy. Most diagnoses are a process of elimination. After eliminating all other possibilities, the medical guesswork begins:

  • If the patient has a memory disorder, it’s Alzheimer’s disease.
  • If they have a movement disorder, it’s Parkinson’s disease.
  • If the patient shows both symptoms, flip a coin.
  • If they ever had a concussion, it’s possibly CTE.
  • If the person is incapacitated, it’s Creutzfeldt-Jakob disease (CJD).

Prion disease causes memory loss, impaired coordination, and abnormal movements. Abnormal proteins are now associated with autism. In fact, it appears that the biggest difference between the neurodegenerative disease spectrum and autism spectrum disorders is age. Both spectrums share common environmental causes and pathologies.

Alzheimer's disease public relations firm

Crossbow Communications specializes in issue management and public affairs. Neurodegenerative disease is among our special areas of practice. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Alzheimer’s Disease Awareness Month

Answers To Alzheimer’s Begin With The Truth

President Ronald Reagan designated November as National Alzheimer’s Disease Awareness Month in 1983. At the time, fewer than 2 million Americans had Alzheimer’s; today, the number of people diagnosed (and still alive) with the disease has soared to nearly 5.4 million. The X factor is the millions who are going undiagnosed and misdiagnosed.

Mayors in cities around the nation are declaring November Alzheimer’s Disease Awareness and Caregivers Month.

Alzheimer’s disease is the sixth-leading cause, and the fastest-growing cause, of death in the United States (and the world), which has some of the highest rates of Alzheimer’s disease in the world. Finland, Sweden and Iceland also are at the top of the list. However, states such as Washington, North Dakota and South Dakota rival the rates found in Scandinavian countries.

Alzheimer's disease treatment

Unfortunately, Alzheimer’s disease is going undiagnosed and misdiagnosed at an escalating pace. Many people, for example, have had diagnoses withheld by their doctors. The epidemic is more widespread than anyone knows. Physicians have withheld millions of diagnoses from patients and their families. According to the Alzheimer’s Association, physicians in the U.S. only inform 45 percent of patients about their Alzheimer’s diagnosis. The same suppression is likely at work in most countries. Meanwhile, millions more go undiagnosed and misdiagnosed.

A groundbreaking study suggested that Alzheimer’s disease causes six times as many deaths as the official statistics would indicate. The Centers for Disease Control and Prevention estimated that, in 2010, Alzheimer’s caused almost 84,000 deaths in the United States, a number derived from death certificates in which Alzheimer’s disease was listed as the main cause. But, in reality, the study said Alzheimer’s was the underlying cause in more than 500,000 deaths in 2010 that were often attributed to conditions, such as pneumonia, caused by complications of Alzheimer’s. Those numbers make Alzheimer’s disease the third-leading cause of death in the United States, behind heart disease and cancer. The study was led by researchers at the Rush University Medical Center in Chicago and published in 2013 in the medical journal Neurology.

Meanwhile, no one is talking about the fact that most forms of neurodegenerative disease, including Alzheimer’s disease, is transmissible. Spouses of those with Alzheimer’s disease, for example, are 600 percent more likely to contract the disease. Other caregivers also are in harm’s way. In fact, entire communities are at risk of exposure.

prion disease spectrum

According to neuroscientists Dr. Laura Manuelidis, at least 25 percent of Alzheimer’s diagnoses are not Alzheimer’s disease. These misdiagnoses are actually CJD, which is further up the prion spectrum. CJD, without dispute, is extremely infectious to caregivers and loved ones but it has not been declared a reportable disease in the U.S. and many other nations. Millions of cases of deadly CJD are being misdiagnosed as Alzheimer’s disease. Millions of patients and caregivers are being misinformed, misguided and exposed to an aggressive disease. Misdiagnosis and misinformation regarding prion disease is a matter of life and death. The disease is now striking young people, including teenagers, with much greater frequency. It’s also killing clusters of people in the same communities with greater frequency.

It’s not known which patients with brain disease become infectious or when, but both CJD and Alzheimer’s patients are being mismanaged. Informed neurologists won’t touch patients with these symptoms because of the risk of transmission. They are making diagnoses from across the room.

“Creutzfeldt-Jakob disease behaves like Alzheimer’s disease on steroids,” said Dr. Jennifer Majersik, an associate professor of neurology at the University of Utah.

On average, Alzheimer’s follows a 14-year course from onset of symptoms until death. For most patients, symptoms go undiagnosed and untreated for at least seven years. For most patients, symptoms go undiagnosed and untreated for at least seven years, during which time the lesions spread through the brain and cause irreparable damage, said Dennis Fortier, author of the Brain Today blog.

 

“With a good diet, physical exercise, social engagement, and certain drugs, many patients (especially those detected at an early stage) can meaningfully alter the course of Alzheimer’s and preserve their quality of life,” Fortier said. “No cure does not mean that there is no treatment.”

The health of the brain is affected by our overall health. Research shows that high cholesterol, high blood pressure, and obesity increase the risk for cognitive decline. A healthy brain requires strong blood flow and plenty of oxygen.

Meanwhile, we can’t forget that:

  • Women are contracting neurodegenerative disease at twice the rate of men;
  • Spouses of those with Alzheimer’s disease are 600% more likely to contract the disease, which is further evidence that it is a transmissible disease. Caregivers, family members and others are in harm’s way because of disease mismanagement and misinformation;
  • People in Finland, Iceland, Sweden and the United States have the highest prevalence of Alzheimer’s disease. Rates in North Dakota, South Dakota and Washington rival the highest rates in the world. Sewage mismanagement and the mismanagement of other forms of infectious waste are responsible for much of the epidemic in these regions and beyond;

We can’t ignore that the global Alzheimer’s disease epidemic and the autism epidemic both began to rise in the late 1970s. They proceeded to spike dramatically in the late 1980s and early 1990s. The spikes in autism and Alzheimer’s disease are almost identical in terms of timing and trajectory. The surge in chronic wasting disease among deer also follows the same trend. These devastating diseases are symptoms of a much bigger problem associated with toxic and infectious waste. Industry policies and practices changed dramatically, which triggered an explosion in brain disease.

According to a 2010 study by the Centers for Disease Control, Utah, North Carolina and New Jersey have the highest rates of autism. ASD strikes one in every 32 Utah boys, and one in every 85 girls. In New Jersey, one in every 28 boys has ASD. The numbers are likely still rising.

Thanks to modern sewage disposal and antiquated risk assessments, we’re witnessing a public health disaster that’s still unfolding in the form of autism, Alzheimer’s disease, west Nile virus, Zika virus, chronic wasting disease, valley fever, meningitis, hepatitis, and other threats to public health.

biosolids land application sewage sludge

Read more about the autism epidemic and its connection to infectious proteins and other neurotoxins that are spreading through biosolids and wastewater reclamation. Please contact us to share your insights, opinions and support for critical reforms.

Alzheimer's disease public relations firm

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise.

 

Prion Surveillance Center Fighting For Life

Alzheimer’s, Creutzfeldt-Jakob, Mad Cow and Chronic Wasting All Caused By Prions

By John Fauber, Reporter, MedPage Today

When Tim Suroviak developed cognitive problems after coming home following heart surgery last year, one of the first questions doctors asked was whether he was a hunter. He was not, though his family did eat venison a few times year.

Suroviak, 63, deteriorated quickly from a rare brain condition known as Creutzfeldt-Jakob disease (CJD). The disease is in the same family as chronic wasting disease, which is endemic in Wisconsin’s deer herd. The Suroviaks live in Wausau, Wisconsin.

After his death, Suroviak’s brain was sent to a lab in Ohio, which led to some shocking news for the family: The type of CJD he had was especially rare, caused by a genetic defect.

That discovery allowed family members to be tested for the disease. So far, no one, including his two daughters, carries the mutation, said Suroviak’s wife, Monica.

But the search for rare prion diseases, whether genetic, sporadic, or potentially caused by eating meat from infected animals, could be curtailed beginning next year.

Prions and Alzheimer's disease

The country’s prion disease surveillance center that looks for new brain disorders would lose all of its federal funding and cease operations under President Trump’s proposed fiscal 2018 budget.

For 20 years, the brains of people who died of suspected prion diseases, such as Creutzfeldt-Jakob disease, have been sent to the National Prion Disease Pathology Surveillance Center at Case Western Reserve University in Cleveland.

The center also is the only licensed lab that can test spinal fluid from living people who have suspected Creutzfeldt-Jakob disease. Such tests can allow families to find out if someone has the disease and what type it is, and then plan how to spend the person’s remaining months. The disease is always fatal.

The loss in funding would come at a time of heightened concern over whether chronic wasting disease can infect people. Recent research showed that it could infect monkeys that were fed venison from infected deer.

At the same time, the number of Creutzfeldt-Jakob cases has jumped substantially nationally and especially in Wisconsin, where chronic wasting disease has now been identified in wild deer in 18 counties. For now, officials attribute the increase to better surveillance and an aging population.

chronic wasting disease

“I don’t know why we want to stop surveillance at a time like this,” said Debbie Yobs, president of the Creutzfeldt-Jakob Disease Foundation. “It doesn’t seem logical.”

The foundation is a nonprofit organization that supports families affected by prion diseases, as well as raising awareness and supporting medical research.

For the Suroviaks, the lab provided peace of mind. First, it let the family know that Tim had a genetic form of the disease, which occurs in between 5 percent and 15 percent of cases. Overall, Creutzfeldt-Jakob disease occurs in about 1 to 1.5 one million people a year worldwide with the vast majority being the sporadic type, meaning the cause is unknown.

While no family members have tested positive for the disease, it turns out that two first cousins of Suroviak died of the disease, Monica Suroviak said.

“If the testing had not been done, we would have never known,” she said.

In 2002, the year CWD was discovered in Wisconsin, six cases of Creutzfeldt-Jakob disease were recorded in the state, according to the Department of Health Services. In two of the last four years, 13 cases have been recorded in the state. That’s a 117 percent increase.

Nationally, there also has been an increase in Creutzfeldt-Jakob cases. In 2002, there were 260 cases, compared with 481 in 2015, an 85 percent increase, according to data from the CDC.

mad cow disease

Creutzfeldt-Jakob is closely related to the form of mad cow disease that infected people, primarily in Great Britain, in the late 1990s and early 2000s, after they ate beef from infected cows. Indeed, human mad cow disease is known as variant Creutzfeldt-Jakob. Both diseases attack the brain, and death usually occurs within a year.

Chronic wasting disease now is in 21 states, primarily in the Upper Midwest and Rocky Mountain states.

Mark Zabel, a prion researcher at Colorado State University, said chronic wasting disease may be mutating and someday could infect people, if it hasn’t already.

“If you don’t have a prion surveillance center that looks for it, you are going to miss it,” he said. “Then, it probably is going to be too late.”

About 400 brains are sent to the prion surveillance center each year. Since 1997 it has contracted with the CDC to provide prion disease surveillance. It has developed a vast library of tissue samples that help show how prion diseases manifest and mutate in people.

Prion diseases are not static; they evolve, Jiri Safar, MD, director of the prion surveillance center and a professor of pathology and neurology at Case Western, said.

“We do not have evidence of a jump to humans, but that is the concern among many in the public health and research community,” he said. (Editor’s Note: There also is no evidence of a reliable species barrier.)

The federal government spends about $6 million a year supporting prion disease surveillance.

Christine Pearson, a spokesperson for the CDC, would not say whether it supported the budget cut.

“The President’s budget is an important part of the federal appropriation cycle; however, Congress will determine final funding levels for all federal agencies,” she said in an email.

Thanks to the Milwaukee Journal Sentinel and MedPage Today for the great report.

Prion Disease News

Alzheimer's disease public relations firm

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Is Alzheimer’s Disease Contagious

Science, Evidence Proving That Alzheimer’s A Transmissible Disease

If you think that you and your family are immune to the surging epidemic of neurodegenerative disease, think again. Neurodegenerative disease, including Alzheimer’s disease, is the fastest-growing cause of death in the world. It’s getting worse every day thanks to mismanagement and misinformation.

Infectious proteins known as prions are involved with most forms of neurodegenerative disease. Prion disease is known in neurology as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” The global epidemic has more to do with the prion contagion than age.

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing deadly prions and prion disease. Prusiner claims that all TSEs, includingAlzheimer’s disease, are caused by prions.

Prions and Alzheimer's disease

President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. According to Prusiner, TSEs are a spectrum disease. Creutzfeldt-Jakob disease, which is extremely aggressive and extremely transmissible, is at the extreme end of the spectrum. Unfortunately, Prusiner’s science is being ignored and we are facing a public health disaster because of the negligence.

Neurologists are just guessing when they make a diagnosis on the prion spectrum. If the patient exhibits memory problems, they are labeled with Alzheimer’s disease. If they have a movement disorder, they are diagnosed with Parkinson’s disease. If the person exhibits extreme symptoms of both, they are diagnosed with Creutzfeldt-Jakob disease (CJD). It’s far from a science. Neurologists don’t know where along the spectrum the disease becomes transmissible. The entire spectrum could represent a transmissible disease. Unfortunately, neurologists are not warning these patients and their caregivers about the risks of exposure. Even those with Creutzfeldt-Jakob disease are not quarantined. They are sent home, where they can infect friends, family, caregivers, clinics, dental offices, restaurants and entire communities.

“There has been a resurgence of this sort of thinking, because there is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A study published in the journal Nature renews concern about the transmissibility of Alzheimer’s disease between people. A second study released in early 2016 by the same scientist adds to the stack of evidence.

According to neuroscientist Laura Manuelidis, at least 25 percent of Alzheimer’s diagnoses are wrong. These misdiagnoses are actually CJD, which is further up the prion spectrum. CJD, without dispute, is extremely infectious to caregivers and loved ones.

Alzheimer's disease and caregivers

Studies confirm that people and animals dying of prion disease contaminate the environment around them with prions because prions are in the skin, urine, feces, blood, mucus and saliva of each victim. Each victim becomes an incubator and a distributor of the Pandora-like pathogen. Victims are contagious long before they exhibit clinical symptoms.

At the personal level, this is very bad news for caregivers, especially spouses, who are 600 percent more likely to contract neurodegenerative disease from patients (Duke University and Utah State University). A cough, sneeze, utensils and drinking glasses all become lethal pathways. Once an item is contaminated, it’s impossible to sterilize. The human prion is resistant to both heat and chemicals. It’s reported that prions released from people are up to a hundred thousand times more difficult to deactivate than prions from most animals. Prions are not alive, so they can’t be killed.

Wastewater treatment plants are collecting points for prions from infected humans. The sewage treatment process can’t stop prions from migrating, mutating and multiplying before being discharged into the environment where they can kill again. The bad news is that the prions are being released back into the environment and dumped openly on land. The wastewater is being reclaimed and used for irrigating crops, parks, golf courses. It’s even being recycled as drinking water.

wastewater treatment plant

Claudio Soto, PhD, professor of neurology at the University of Texas Medical School in Houston, and his colleagues confirmed the presence of prions in urine. Soto also confirmed that plants uptake prions and are infectious and deadly to those who consume the infected plants. Therefore, humans, wildlife and livestock are vulnerable to prion disease via plants grown on land treated with sewage sludge and reclaimed sewage water.

Prion researcher Dr. Joel Pedersen, from the University of Wisconsin, found that prions become 680 times more infectious in certain soils. Pedersen also found that sewage treatment does not inactivate prions. Therefore, prions are lethal, mutating, migrating and multiplying everywhere sewage is dumped.

“Our results suggest that if prions enter municipal wastewater treatment systems, most of the agent would bond to sewage sludge, survive anaerobic digestion, and be present in treated biosolids,” Pedersen said.

joel pedersen prion research

“Land application of biosolids containing prions represents a route for their unintentional introduction into the environment. Our results emphasize the importance of keeping prions out of municipal wastewater treatment systems. Prions could end up in sewage treatment plants via slaughterhouses, hospitals, dental offices and mortuaries just to name a few of the pathways. The disposal of sludge represents the greatest risk of spreading prion contamination in the environment. Plus, we know that sewage sludge pathogens, pharmaceutical residue and chemical pollutants are taken up by plants and vegetables.”

Thanks to more and more people dying from TSEs, wastewater treatment systems are more contaminated with prions than ever. Wastewater treatment plants are now prion incubators and distributors. The prion problem is getting worse every day.

biosolids land application sewage sludge

The U.S. Environmental Protection Agency (EPA) has confirmed that prions are in sewage and that there has been no way to detect them or stop them. As such, the EPA has never issued guidance on prion management within wastewater treatment plants. Unfortunately, the EPA’s risk assessment on sewage sludge and biosolids were prepared before the world of science knew about prions. The agency continues to cling to its antiquated sludge rule crafted back in the dark ages. It does, however, consider prions a “contaminant of emerging concern.” Meanwhile, its outdated risk assessments are promoting a public health disaster.

“Since it’s unlikely that the sewage treatment process can effectively deactivate prions, adopting measures to prevent the entry of prions into the sewer system is advisable,” said the Toronto Department of Health, November 2004.

Exposing crops and livestock to prions is a very bad idea. Plants absorb prions from the soil along with water and nutrient uptake, which makes the prions even more bioavailable and infectious to humans, wildlife and livestock.

chronic wasting disease

Unfortunately, the damage is real. Deer, elk, moose and reindeer are contracting an unstoppable prion disease now. In deer, the government calls prion disease chronic wasting disease. In cattle, prion disease is called bovine spongiform encephalopathy (they might as well call it what it is—transmissible spongiform encephalopathy). Mad cow disease is the term that most of us know. The government pretends that there is a specific prion responsible for each of these diseases. The fact is that there are thousands of mutations of prions spreading in the environment and food chain now. Some kill quickly, while some are less lethal. The only thing that we need to know is that a deadly prion is a deadly prion. There is no species barrier.

mad cow disease

If prion disease is killing these animals, livestock are not immune. Beef and dairy cattle are consuming these infected crops and the infected water supplies, too. Since humans are at the top of the food chain, and since we are often downstream from these infected farms, ranches and forests, our food and water supplies are being compromised. Wind and tornadoes transport the infectious waste even further.

So, is Alzheimer’s disease transmissible? There is absolutely no evidence to the contrary. The truth is your best defense against neurodegenerative disease. It’s time to demand reforms on many levels to safeguard caregivers, family members and our food and water supplies. Despite all of the warning signs, government and industry are insisting that we waste more time, money and lives studying these issues to death. The infection is real. The body count is real. The denial is disturbing.

Alzheimer’s Disease Research via http://crossbowcommunications.com/is-alzheimers-disease-contagious/

Alzheimer's disease public relations firm

Crossbow Communications specializes in issue management and public affairs. Alzheimer’s disease, Creutzfeldt-Jakob disease, chronic wasting disease and the prion disease epidemic is an area of special expertise. Please contact Gary Chandler to join our coalition for reform gary@crossbow1.com.

Neurodegenerative Disease A Global Epidemic

Neurodegenerative Disease The Fastest Growing Cause Of Death

Death rates from heart disease and cancer are dropping globally due to advances in nutrition, medicine and disease management. Meanwhile, neurodegenerative disease is exploding because it’s highly contagious in most cases.

In the U.S., deaths from Alzheimer’s disease increased 71 percent from 2000 to 2013, while those attributed to heart disease decreased 14 percent. Similar trends are emerging around the world. Unfortunately, the global spike in autism shares the same timing and trajectory as the surge in neurodegenerative disease. It’s not just a coincidence. The correlation is real thanks to reckless policies and practices. It appears that the biggest difference between autism and classic forms of neurodegenerative disease is age of onset.

The actual epidemic is larger than anyone knows. Physicians are withholding millions of diagnoses from patients and their families. According to the Alzheimer’s Association, physicians in the U.S. only inform 45 percent of patients about their Alzheimer’s disease diagnosis. The same suppression is likely at work in most countries. Meanwhile, millions more go undiagnosed and misdiagnosed. Women face an elevated risk of Alzheimer’s disease.

Prions and Alzheimer's disease

Dr. Stanley Prusiner, an American neuroscientist from the University of California at San Francisco, earned a Nobel Prize in 1997 for discovering and characterizing prions (PREE-ons) and prion disease, also known as transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” Prions are a deadly and unstoppable form of protein that migrates, mutates, multiplies and kills with unparalleled efficiency.

President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his research. Unfortunately, Prusiner’s science is being ignored and we all are facing a public health disaster because of the negligence and reckless disregard for public health.

TSE is a spectrum disease also known as prion disease. The spectrum includes Alzheimer’s disease, Parkinson’s disease and an extremely aggressive version known as Creutzfeldt-Jakob disease. Prusiner claims that all forms of TSE are caused by infectious prions. The prion spectrum varies in severity. It also varies depending on which region of the brain is impacted first. When the presenting symptom is memory loss, the diagnoses flow along the following chart.

prion disease spectrum

Prion disease is a spectrum disease that varies in severity. It also varies depending on which region of the brain is impacted first. It affects most, if not all, mammals. Prion disease causes memory loss, impaired coordination, and abnormal movements. It’s not known which patients with brain disease become infectious or when, but both CJD and Alzheimer’s patients are being mismanaged. The most savvy neurologists won’t touch patients with these symptoms because of the risk of infection. They are making diagnoses from across the room. Unfortunately, caregivers aren’t warned accordingly.

“CJD behaves like Alzheimer’s disease on steroids,” said Dr. Jennifer Majersik, an associate professor of neurology at the University of Utah.

According to neuroscientist Laura Manuelidis, at least 25 percent of Alzheimer’s diagnoses are not Alzheimer’s disease. These misdiagnoses are actually CJD, which is further up the prion spectrum. CJD, without dispute, is extremely infectious to caregivers and loved ones. Millions of cases of deadly CJD are being misdiagnosed as Alzheimer’s disease. Millions of patients and caregivers are being misinformed, misguided and exposed to an aggressive disease. Misdiagnosis and misinformation regarding prion disease is a matter of life and death. The mismanagement doesn’t end here.

Prions are now the X factor and they are not being accounted for by industry or government. Prions are an infectious form of glycoprotein that can spread throughout the body.

“There has been a resurgence of this sort of thinking, because there is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins (prions).”

A recent study published in the journal Nature also renews concern about the transmissibility of Alzheimer’s disease between people. A second study by the same scientist in early 2016 adds to the stack of evidence. There is no evidence that Alzheimer’s disease is not infectious to other mammals.

Many factors are contributing to the epidemic. Unfortunately, it appears that Alzheimer’s disease and Parkinson’s disease are just as infectious as Creutzfeldt-Jakob disease. Studies confirm that people and animals dying of prion disease contaminate the environment around them with prions because prions are in the urine, feces, blood, mucus and saliva of each victim.

Alzheimer's disease infectious disease

Not only are homes, hospitals and nursing homes exposed to the deadly prion pathogen from those with prion disease, so are entire sewage treatment systems and their by-products. Wastewater treatment plants are prion incubators and distributors. The sewage sludge and wastewater released are spreading disease far and wide. Claudio Soto, PhD, professor of neurology at the University of Texas Medical School in Houston, and his colleagues confirmed the presence of prions in urine.

Prion researcher Dr. Joel Pedersen, from the University of Wisconsin, found that prions become 680 times more infectious in certain soils. Pedersen also found that sewage treatment does not inactivate prions. Therefore, prions are lethal, mutating, migrating and multiplying everywhere sewage is dumped.

“Our results suggest that if prions enter municipal wastewater treatment systems, most of the agent would bond to sewage sludge, survive anaerobic digestion, and be present in treated biosolids,” Pedersen said.

joel pedersen prion research

“Land application of biosolids containing prions represents a route for their unintentional introduction into the environment. Our results emphasize the importance of keeping prions out of municipal wastewater treatment systems. Prions could end up in sewage treatment plants via slaughterhouses, hospitals, dental offices and mortuaries just to name a few of the pathways. The disposal of sludge represents the greatest risk of spreading prion contamination in the environment. Plus, we know that sewage sludge pathogens, pharmaceutical residue and chemical pollutants are taken up by plants and vegetables.”

Each victim becomes an incubator and a distributor of the Pandora-like pathogen. The human prion is resistant to both heat and chemicals. It’s reported that prions released from people are up to a hundred thousand times more difficult to deactivate than prions from most animals.

biosolids land application sewage sludge

Sewage from hospitals, nursing homes, slaughterhouses, morgues, mortuaries, veterinarians and other high-risk places enters the same sewage system. Thanks to more and more people dying from TSEs, sewage systems are more contaminated with prions than ever. Wastewater treatment systems are now prion incubators and distributors.

The U.S. Environmental Protection Agency (EPA) has confirmed that prions are in sewage and that there has been no way to detect them or stop them. As such, the EPA has never issued guidance on prion management within wastewater treatment plants. Unfortunately, the EPA’s risk assessment on sewage sludge and biosolids were prepared before the world of science knew about prions. The agency continues to cling to it’s antiquated sludge rule crafted back in the dark ages. It does, however, consider prions a “emerging contaminant of concern.” Meanwhile, its outdated risk assessments are promoting a public health disaster.

“Since it’s unlikely that the sewage treatment process can effectively deactivate prions, adopting measures to prevent the entry of prions into the sewer system is advisable,” said the Toronto Department of Health, November 2004.

Researchers have more questions than answers about brain disease, but we know that neurotoxins, head trauma and genetics can all trigger neurodegenerative disease. Unfortunately, that’s where our knowledge gets fuzzy.

When the U.S. government enacted the Bioterrorism Preparedness and Response Act of 2002, it classified prions as select agents that pose an extreme risk to food, water and much more. TSE surveillance is important for public health and food safety because TSEs have the potential of crossing from animals to humans, as seen with the spread of mad cow disease. TSEs also have the potential of being transmitted from humans to animals. The most common example is chronic wasting disease among deer species. Deer, elk, moose, reindeer and many other animals are being exposed to infectious waste in sewage.

Prions are unstoppable. The pathogen spreads through the bodily fluids and cell tissue of its victims. The blood, saliva, mucus, milk, urine and feces of victims are infectious. Wastewater treatment doesn’t touch prions. In fact, these facilities are now helping incubate and distribute prions via solids and wastewater released.

biosolids land application contaminates food water

Once unleashed on the environment, prions remain infectious. They migrate, mutate and multiply as they infect crops, water supplies and more. Unfortunately, prions linger in the environment, homes, hospitals, nursing homes, dental offices and beyond infinitely. Prions defy all attempts at sterilization and inactivation. If they can’t stop prions in the friendly and sterile confines of an operating room, they can’t stop them in the wastewater treatment plant.

Prions shed from humans are the most deadly. They demand more respect than radiation. They’re being ignored by regulators and industry alike. As such, food and water sources are being contaminated with the deadliest forms of prions. Homes, nursing homes, hospitals, clinics and restaurants are other examples of public places that are being contaminated by prions from victims of prion disease.

The deadly prion spectrum also includes mad cow disease and chronic wasting disease among deer. Scientists have shown that infected tissues can transmit prion disease between animals. There is no species barrier.

Although there are many causes and pathways contributing to prion disease, many pathways are being mismanaged around the globe. Not only are homes and hospitals exposed to the prion pathogen, so are entire sewage treatment systems. Wastewater treatment plants are prion incubators. Sewage sludge and wastewater pumped out spread the disease.

wastewater treatment plant

Sewage treatment plants can’t detect or stop deadly prions. Just ask the U.S. EPA. Dumping sewage sludge (biosolids) from billions of people on land and at sea spreads prions far and wide. It also spreads heavy metals, radioactive waste, carcinogens, pharmaceuticals and more. It’s time for the truth. It’s time for reforms that can safeguard us from this public health disaster.

Read more about the correlation between Alzheimer’s disease, autism and sewage mismanagement. http://alzheimerdisease.tv/autism/

autism population

Background On Sewage Sludge

In 1972, world leaders admitted that dumping highly toxic sewage sludge into the oceans killed entire underwater ecosystems and threatened public health. Some nations stopped the dumping immediately and started dumping it on land or burning it in incinerators. The most responsible cities started putting sewage sludge in landfills. Meanwhile, the United States allowed cities to keep dumping sewage sludge at sea for another 20 years. It finally passed the Ocean Dumping Ban Act of 1988, when beaches along the east coast were forced to close because of high levels of pathogens from sewage that washed up on shore.

land application sewage sludge and disease

The law prohibited all dumping of industrial waste and municipal sewage sludge into our oceans after December 31, 1991. It did nothing however, to keep cities such as Boston and Los Angeles from dumping millions of gallons of raw sewage directly into the oceans every day, but with the help of the U.S. EPA, the Act did redirect millions of tons of deadly toxins and pathogens from our oceans to farms, ranches, national forests, city parks, golf courses, playgrounds, fair grounds, race tracks, sport fields and beyond. From there, the pathogens began contaminating food, water and air as they were soaked up by crops, swept away by rainwater and picked up by windstorms, tornadoes and hurricanes and dumped on innocent citizens where they live, work and play. The runoff still contaminates our oceans after it filters through our creeks, lakes and rivers.

After the 1991 ban on ocean dumping, the EPA instituted a policy of sewage sludge reuse on agricultural land. It hired a PR firm to spin a new brand for the death dirt. They crafted the clever name “biosolids” to help disguise the hazards. The EPA promoted biosolids recycling throughout the 1990s. Unfortunately, the risk assessments were severely biased and flawed. The proof is in the pudding.

This new form of sewage dispersal has sparked a public health disaster that’s still unfolding in the form of autism, Alzheimer’s disease, west Nile virus, Zika virus, chronic wasting disease, meningitis, hepatitis, and other threats to public health. The risk assessments for these practices failed to account for heavy metals, pharmaceutical residue, radionuclides, carcinogens and a deadly form of protein known as a prion (which was unknown to the world of science at the time). The practice sparked a public health disaster in exchange for healthier oceans and a very profitable new industry. The EPA even took its show on the road and convinced other nations to use its faulty risk assessments to justify multi-million dollar contracts for these new corporations. Countries such as Canada took the bait hook, line and sinker and never conducted its own risk assessments.

Chronic wasting disease is now rampant among deer and elk in Canada and it recently jumped the Atlantic to Norway’s reindeer herd. It’s spreading across the U.S. like wildfire as we spread more pathogens and lies. Land application sites often involve locations where poverty is high and economic prosperity is low, which means resistance is low. Sludge tends to be dumped where minorities live, leading to allegations of environmental racism. Unfortunately, contaminated food and water make it back to the cities where the infectious waste originated.

Treated sewage sludge has been used in the UK, Europe and China agriculturally for more than 80 years, though there is increasing pressure in some countries to stop the practice of land application due to farm land contamination and public outrage. In the 1990s there was pressure in some European countries to ban the use of sewage sludge as a fertilizer. Switzerland, Sweden, Austria, and others introduced a ban to safeguard public health. Others should follow their example.

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Wastewater Treatment Plants Spreading Brain Disease

Alzheimer’s Disease An Infectious Disease

Neurodegenerative diseases are the fastest-growing causes of death around the world. The mismanagement of infectious waste is contributing to the epidemic.

Dr. Stanley Prusiner earned a Nobel Prize in 1997 for his pioneering research on deadly prions—an infectious form of protein that connects a deadly spectrum disease called transmissible spongiform encephalopathy (TSE). The operative word is “transmissible.” TSEs include Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease, mad cow disease and chronic wasting disease in deer, elk, moose and reindeer. TSE is also killing dolphins, whales, camels and many other species of mammals. It’s the environmental equivalent of Pandora’s Box. Actually, it’s Pandora’s Lunchbox.

Prions and Alzheimer's disease

President Obama awarded Prusiner the National Medal of Science in 2010 to recognize the importance of his work. Unfortunately, this groundbreaking research is being ignored. This negligence is fueling a public health disaster around the world, as critical pathways are being ignored and mismanaged. The mismanagement also is contributing to the global surge in autism.

In June 2012, Prusiner confirmed that Alzheimer’s, Parkinson’s, Huntington’s and even ALS are prion diseases similar, if not identical, to Creutzfeldt-Jakob disease. The primary difference being which part of the brain the disease attacks first. The other variable is that there are now an unknown number of prion mutations. Mutations of these deadly prions are the common denominator between all forms of TSEs. Most of the carnage is being swept under the rug as the problem escalates.

“There is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins.”

Although there are many causes contributing to prion disease, many people and animals are contracting it from environmental exposure (food, water and soil) and then contaminating the environment even more with their own bodily fluids. Victims of prion disease are walking time bombs. Creutzfeldt-Jakob disease (CJD) is the most deadly form of prion disease in humans. Without dispute, it is a very contagious disease that kills rapidly. There is no cure for CJD, Alzheimer’s and other forms of prion disease.

Alzheimer’s and CJD are often indistinguishable to neurologists and general practitioners. Misdiagnoses are common. It appears that CJD is caused by a more aggressive mutation of prion than Alzheimer’s, but a deadly prion is a deadly prion. There is no reason to believe that some prions behave differently than others in disease transmission and progression. There should be no difference in disease management.

Unfortunately, as more people contract these brain diseases, the more deadly wastewater streams become. Meanwhile, wastewater reuse is surging around the world in response to growing populations and dwindling water resources. Other by-products from the wastewater stream known as biosolids (sewage sludge) also are being used to fertilize crops, pastures for livestock, golf courses, playgrounds and gardens. Millions of people, including your family, are in harm’s way because wastewater treatment plants can’t stop prions.

joel pedersen prion research

Prion researcher Dr. Joel Pedersen, from the University of Wisconsin, found that prions become 680 times more infectious in certain soils. Pedersen also found that sewage treatment does not inactivate prions. Therefore, prions are lethal, mutating, migrating and multiplying everywhere sewage is dumped.

“Our results suggest that if prions enter municipal wastewater treatment systems, most of the agent would bond to sewage sludge, survive anaerobic digestion, and be present in treated biosolids,” Pedersen said. “Land application of biosolids containing prions represents a route for their unintentional introduction into the environment. Our results emphasize the importance of keeping prions out of municipal wastewater treatment systems.

Prions could end up in sewage treatment plants via slaughterhouses, hospitals, dental offices and mortuaries just to name a few of the pathways. The disposal of sludge represents the greatest risk of spreading prion contamination in the environment. Plus, we know that sewage sludge pathogens, pharmaceutical residue and chemical pollutants are absorbed by plants and vegetables grown in sewage sludge.”

Regulators and industry are playing dumb as the body count keeps rising. It’s a deadly circle enabled by an outdated risk assessment. Modern science is being ignored.

The largest prion pathway in the world is wastewater (infectious waste) from homes, hospitals, nursing homes, slaughterhouses, dental offices and other high-risk sources. The problem is that prions are in all bodily fluids and cell tissue of millions of victims who often go undiagnosed. Their mucus, saliva, feces, and urine are flushed down millions of toilets and rinsed down sinks every day. Once inside the wastewater system, prions proceed to migrate, mutate and multiply. Reckless risk assessments enable wastewater treatment plants to spread these deadly agents far and wide. Deadly prions are building up and incubating in wastewater treatment plants and then dumped openly on land. They are swept into the air by the wind. Now, water contaminated by prions is migrating into our rivers, lakes and oceans. It’s being injected into groundwater and it’s being recycled as tap water.

biosolids land application sewage sludge

I used to support wastewater reclamation and reuse projects until I realized that the risk assessments were prepared decades ago—before Dr. Prusiner characterized prions and prion disease. These microscopic protein particles have converted sewage and its by-products a public health disaster.

Read The Full Story About Prion Disease and Alzheimer’s Disease At http://crossbowcommunications.com/wastewater-reclamation-reuse-based-on-outdated-risk-assessments/

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Key Proteins Found In Early Phases Of Alzheimer’s Disease

Tau, Amyloid Detection Could Improve Diagnostic Capabilities

Researchers from Aberdeen have identified changes in the brains of those suffering early signs of Alzheimer’s disease.

A University of Aberdeen study confirmed for the first time that two proteins, assumed to contribute to the disease process, are both present at very early stages of Alzheimer’s disease. Both are present in an area of the brain that is involved in memory formation and information processing–the hippocampus.

Alzheimer's disease and caregivers

The Alzheimer’s Research UK funded the research, which will have implications for the development of new drugs, but may also provide important information for diagnosis of the disease. 

The team, led by Dr Koss and Professor Bettina Platt, used human brain samples provided by the Brains for Dementia Research platform to investigate changes in the brain at different stages of the disease. The researchers developed novel ways to study two proteins (tau and amyloid), both associated with Alzheimer’s disease, and determined how each one contributed to the onset, progression and symptoms of the disease.

“The entire research community is in agreement that it’s important to diagnose Alzheimer’s disease early,” said Dr. Koss. “Our findings will go some way to help achieve this. These early-stage changes in the brains of people with Alzheimer’s disease highlight key biochemical processes that may not only enable improved diagnostic procedures but may also inform drug development.”

Early diagnosis also can help protect caregivers and others from the transmission of Alzheimer’s disease. It’s likely spreading through the bodily fluids of victims. Items exposed, including drinking glasses, utensils are impossible to sterilize.

“There is now real evidence of the potential transmissibility of Alzheimer’s,” says Thomas Wiesniewski M.D. a prion and Alzheimer’s researcher at New York University School of Medicine. “In fact, this ability to transmit an abnormal conformation is probably a universal property of amyloid-forming proteins.”

Prions and Alzheimer's disease

Alzheimer’s Disease Research Report via https://www.eveningexpress.co.uk/fp/news/local/study-identifies-disease-changes/