Alzheimer’s Disease Connected To Diabetes
Humanin is an amino acid known to play many roles in the human body. Alzheimer’s defense may be one of those roles. Humanin is a potential therapeutic agent for Alzheimer’s disease, and its derivative, S14 G-humanin, is much stronger in its neuroprotective effect against Alzheimer’s disease-relevant insults. Although effective, the detailed molecular mechanism through which S14 G-humanin exerts its effects remains unclear.
A recent study by Xue Li and colleagues from Henan Provincial People’s Hospital, China investigated the inhibitory effects of S14G-humanin on amyloid-beta protein-induced hippocampal neuronal injury, and data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exhibiting a potential and effective treatment for Alzheimer’s disease.
These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).