Alzheimer’s An Infectious Disease Like Mad Cow, CJD

TSEs Transmissible By Definition

The brain damage seen in some cases of Alzheimer’s disease could have its roots in an infectious prion-like disease, such as that seen in bovine spongiform encephalopathy (mad cow) and its human form Creutzfeldt-Jakob disease (CJD), according to an international study published this week in the journal Molecular Psychiatry that was led by the University of Texas Medical School at Houston in the US.

Alzheimers disease epidemic

The researchers injected a small amount of Alzheimer’s disease human brain tissue into the brains of mice bred never to develop this kind of brain alteration, and found the animals gradually developed the disease and that it spread to other parts of the brain.

Alzheimer’s disease is the most common type of senile dementia. It affects memory, thinking and behavior, and gets worse with time. The two main hallmarks of the disease are build-up in the brain of misfolded amyloid beta protein, and twisted fibers of tau protein.

In the US there are 5.4 million people with Alzheimer’s disease, where according to the Alzheimer’s Association, it is the sixth leading cause of death and the only cause of death among the top 10 in the US that cannot be prevented, cured or even slowed.

Although there is compelling evidence that build-up of misfolded amyloid beta is a major factor in the disease, we know very little about what might trigger this in otherwise normal proteins, except that in prion diseases like mad cow disease and CJD, the damage is also due to accumulation of misfolded versions of otherwise normal proteins. Prions are infectious misfolded proteins (the word prion comes from the first two letters of protein and the last three of infection).

Senior author Dr Claudio Soto, professor of neurology at The University of Texas Medical School at Houston, said in a statement:

“The underlying mechanism of Alzheimer’s disease is very similar to the prion diseases. It involves a normal protein that becomes misshapen and is able to spread by transforming good proteins to bad ones.”

“The bad proteins accumulate in the brain, forming plaque deposits that are believed to kill neuron cells in Alzheimer’s,” he added.

Alzheimer's disease research

For their study, Soto and colleagues injected brain tissue from a confirmed Alzheimer’s patient into mice, which, without exposure to such material, would never develop these alterations.

They also injected a similar amount of brain tissue into a second group of similarly bred mice, except in that group (the controls), the injected tissue came from someone who did not have Alzheimer’s.

The results showed that none of the control mice went on to develop signs of Alzheimer’s, while all those injected with Alzheimer’s brain tissue developed plaques and other hallmarks of the disease.

“The accumulation of [amyloid beta] deposits increased progressively with the time after inoculation, and the [amyloid beta] lesions were observed in brain areas far from the injection site,” write the researchers.

They conclude that these findings suggest some of the typical brain abnormalities seen in Alzheimer’s disease “can be induced by a prion-like mechanism of disease transmission through propagation of protein misfolding.”

This could have “broad implications” for understanding the underlying mechanisms that trigger Alzheimer’s, and may help develop ways to prevent and treat the disease, they added.

“We are currently working on whether disease transmission can happen in real life under more natural routes of exposure,” said Soto.

Funds from the George P. and Cynthia W. Mitchell Center for Research in Alzheimer’s Disease and Related Brain Disorders at University of Texas Health (UTHealth) helped pay for the study. Soto is director of the Mitchell Center.

Source: http://www.medicalnewstoday.com/articles/235493.php

About Gary Chandler

Gary Chandler is an author, advocate and strategist on health and environmental issues.
This entry was posted in Alzheimer's Disease Causes, Alzheimer's Disease Research, Contagion, Disease Transmission, Prion Disease and tagged , . Bookmark the permalink.

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